There is now only one chest in the Shrined Giant Cave.

Bard Soloing Shrined Giant Cave Loot Run
A Bard can solo this one on Elete with ease fire protect and invis and run to the big room and jump down and just sing them all to sleep at the bottom and run in to loot the chest and finish out. A no brainer.

Wizard Soloing Shrined Giant Cave Loot Run
As a wizard I invis and fire protect myself and run through all the giants some see me and follow me for a ways. When I get to the large room I hug the wall to the left and drop down behind the mushrooms. set up Dancing Balls and Cloud Kill around and above me. Till all in the area are dead then invis to the chest loot up and Recall or Demnsion Door if I have friends with me.

Azari